| 8/31/2008 | Signed to practice squad: S Jamar Adams, DT Kevin Brown, WR Michael Bumpus, CB Marquis Floyd, G Pat Murray, TE Joe Newton and T Kyle Williams. |
| 8/30/2008 | Placed WR Ben Obomanu and DT Chris Cooper on injured reserve |
| 8/30/2008 | Terminated veteran contracts of WR Bryan Gilmore and DT Larry Tripplett |
| 8/30/2008 | Released DB Jamar Adams, QB Dalton Bell, DT Kevin Brown, WR Michael Bumpus, C Ben Claxton, DB Marquis Floyd, P Reggie Hodges, DB Kelin Johnson, C Nick Jones, FB David Kirtman, G Pat Murray, TE Joe Newton, LB Dallas Sartz, WR Trent Shelton, DE Nu’u Tafisi, T Kyle Williams |
| 8/27/2008 | Released LS Tim Lindsey. Signed LS Jeff Robinson. |
| 8/26/2008 | Released WR Joel Filani and CB Omare Lowe. Placed LB Will Herring on the physically unable to perform list and T William Robinson and LS Tyler Schmitt on injured reserve. |
| 8/13/2008 | Released LB Eric Wicks. Signed LS Tim Lindsey. |
| 8/12/2008 | Signed C Nick Jones |
| 8/11/2008 | Released CB Derrick Johnson and LB Matt Castelo. Signed CB Marquis Floyd and LB Dallas Sartz. Terminated contract of DT Marcus Tubbs. |
| 8/5/2008 | Placed LB Wesly Mallard on injured reserve. Signed CB Derrick Johnson. |
| 8/4/2008 | Placed G Chris Gray on injured reserve. Signed DT Kevin Brown. |
| 8/3/2008 | Placed CB DeMichael Dizer on injured reserve. Signed C Ben Claxton. |
| 7/26/2008 | Released TE Zac Alcorn. Signed TE John Carlson. |
| 7/25/2008 | Signed DE Lawrence Jackson. |
| 7/24/2008 | Released S Mike Green. Signed WR Bryan Gilmore. |
| 7/18/2008 | Released FB Dan Curran. Signed DT Red Bryant. |
| 7/15/2008 | Signed FB Owen Schmitt. |
| 7/10/2008 | Named Matt Berry southwest area scout, Ed Dodds midwest area scout and Eric Stokes west coast area scout. Promoted Jason Barnes from intern to pro personnel assistant. |
| 6/25/2008 | Signed LS Tyler Schmitt and K Brandon Coutu |
| 6/20/2008 | Released G Dustin Dickinson, WR Chas Gessner and C Nick Jones |
| 6/18/2008 | Released CB Donovan Alexander. Signed RB Justin Forsett. |
| 6/4/2008 | Released WR Anthony Russo. Signed WR Trent Shelton. |
| 5/14/2008 | Released C Chris White. Signed WR Chas Gessner. |
| 5/5/2008 | Released DT Kelly Talavou and WR Travis Brown. Signed DT Kevin Brown and WR Joel Filani. |
| 5/2/2008 | Released DT Jonathan Lewis. Signed T Floyd Womack. |
| 4/29/2008 | Released LS Tim Lindsey. Signed DT Larry Tripplett and LB Wesly Mallard. Claimed QB Dalton Bell off waivers from Carolina. |
| 4/27/2008 | Drafted DT Red Bryant in the fourth round, FB Owen Schmitt in the fifth round, LS Tyler Schmitt in the sixth round, RB Justin Forsett and K Brandon Coutu in the seventh round of the NFL Draft. Signed free agents: S Jamar Adams, CB Donovan Alexander, WR Travis Brown, WR Michael Bumpus, LB Matt Castelo, G Dustin Dickinson, CB DeMichael Dizer, LB David Hawthorne, S Kelin Johnson, T William Robinson, WR Anthony Russo, S Eric Wicks. |
| 4/26/2008 | Drafted DE Lawrence Jackson in the first round and TE John Carlson in the second round. |
| 4/22/2008 | Released RB Shaun Alexander. |
| 4/7/2008 | Signed P Reggie Hodges and CB Omare Lowe. |
| 3/27/2008 | Signed K Olindo Mare |
| 3/26/2008 | Re-signed CB Marcus Trufant. |
| 3/25/2008 | Signed DE Chris Cooper and LB D.D. Lewis |
| 3/21/2008 | Signed LB Lofa Tatupu to contract extension |
| 3/11/2008 | Named Kasey Dunn running backs coach. |
| 3/10/2008 | Signed RB Julius Jones. |
| 3/5/2008 | Signed RB T.J. Duckett. |
| 3/4/2008 | Signed TE Jeb Putzier. Named Mike DeBord Offensive Assistant. |
| 2/29/2008 | Released T Tom Ashworth. |
| 2/14/2008 | Named Bill Lazor Quarterbacks Coach. Signed G Mike Wahle. |
| 1/25/2008 | Named Mike Solari offensive line coach |
| 1/15/2008 | Signed TE Zac Alcorn, C Nick Jones, DT Jonathan Lewis, LS Tim Lindsey and C Chris White |
| 1/9/2008 | Signed G Pat Murray |
| 1/7/2008 | Signed FB Dan Curran |
| 1/1/2008 | Placed DE Baraka Atkins on injured reserve. Signed WR Logan Payne from practice squad to actice roster. Signed DT Kelly Talavou to the practice squad. |