Two starters listed as questionable will play in the Seahawks' home-opener vs. the Tennessee Titans, with left cornerback D.J. Reed and left guard Damien Lewis both active for Sunday's game at Lumen Field.

Defensive tackle Bryan Mone, however, is inactive after also being listed as questionable due to an elbow injury. The loss of Mone, who had a career-best five tackles in last week's win at Indianapolis, is a blow to a Seattle run defense gearing up to face Derrick Henry, the reigning NFL Offensive Player of the Year, but Seattle does have a lot of depth on its line, including the addition of defensive tackle Robert Nkemdiche, who was elevated off of the practice squad on Saturday and who is active.

Also active is defensive end L.J. Collier, who was a healthy scratch last week. In addition to Mone, the Seahawks have two other players out due to injury: rookie receiver Dee Eskridge, who was ruled out with a concussion, and running back Rashaad Penny, who was listed as doubtful with a calf injury.

With Penny out, Alex Collins is active after being inactive last week.

The Titans will be without left tackle Taylor Lewan, who was not on Friday's injury report, but who appeared to sustain some sort of injury during pregame warmups. Lewan is coming back from an ACL injury that cut short his 2020 season and the Titans listed him as out with a knee injury. Also inactive for Tennessee after being listed as questionable are starting linebacker Jayon Brown and tight end Anthony Firkser.

Here are the inactives for both teams:

Seattle Seahawks

WR Dee Eskridge
QB Jake Luton
RB Rashaad Penny
CB John Reid
T Stone Forsythe
DT Bryan Mone

Tennessee Titans

LT Taylor Lewan
LB Jayon Brown
TE Anthony Firkser
WR Cameron Batson
CB Caleb Farley
OLB Derick Roberson