3 ESPN experts are picking the Seahawks to beat the 49ers this week in San Fransisco. ESPN's Laura Rutledge, Seth Wickersham, and Damien Woody were the 3/10 experts to choose the Seahawks over the 49ers in this weeks matchup.
CBS Sports NFL's Pete Prisco is picking the 49ers to win by a slight margin of 29-23 over the Seahawks for the Week 2 matchup in San Francisco. "Seattle played well in upsetting the Broncos on Monday night, but now they head out on a short week. That's a challenge. The 49ers didn't play well in the bad conditions at Soldier Field in losing to the Bears but that will change here. Trey Lance gets it going."
NBC Sports Pro Football Talk's Mike Florio is choosing the Seahawks to beat the 49ers in a close 20-17 game. "The Seahawks typically do well against the 49ers, and Trey Lance continues to be a huge question mark."
Adam Jude of The Seattle Times takes the Seahawks over the 49ers in a tight 23-20 game in Week 2. "The Seahawks' dominance of the Niners in the Bay Area continues, with Rashaad Penny and DK Metcalf busting out and Seattle's defense shutting down young Trey Lance."
Sam Farmer of The Los Angeles Times is choosing the 49ers to run away with a 31-17 win at home over the Seahawks. "Seahawks won their Super Bowl last week by sending Russell Wilson home in defeat. The 49ers were humiliated at Chicago and, behind their running game, should bounce back in home opener."
Scott Whittum of Athlon Sports takes the Seahawks to beat the 49ers 20-16 for their first away game of the season. "These two teams have historically played highly competitive games, as six of the last seven games have been decided by one score. The Seahawks are also 17-4 in their previous 21 games against the 49ers. They have not been blown out in San Francisco since a 33-17 loss on Sept. 11, 2011. The Seahawks will do just enough on offense to survive and advance to 2-0 in the young season."
The Seattle Seahawks take on the San Francisco 49ers for Week 15 of the 2022 season. Take a look back at some of their previous matchups.
Seattle Seahawks fullback Dan Doornink (33) runs upfield during an NFL game against the San Francisco 49ers in San Francisco, Oct. 7, 1979. The Seahawks defeated the 49ers 35-24. (AP Photo/Al Messerschmidt)
San Francisco quarterback Joe Montana (16) passes during an NFL football game against Seattle Seahawks on Sunday, Nov. 25, 1985, in San Francisco. The 49ers won the game, 19-6. (AP Photo/Greg Trott)
San Francisco 49ers Ronnie Lott pulls down Seattle Seahawks receiver Steve Largent (80) for a short gain in the first quarter at Candlestick Park in San Francisco, Aug. 29, 1986. (AP Photo/Paul Sakuma)
Jerry Rice (80) of the San Francisco 49ers dives into the endzone for a touchdown after catching a 30-yard pass from Joe Montana during the second quarter on Friday, Sept. 1, 1989 in Seattle, against the Seahawks. Unable to make the play for the Seahawks in Dwayne Harper (29). (AP Photo/Bill Chan)
Seattle Seahawks quarterback Dave Krieg gives the number one sign as he lines up behind Seahawks tackle Andy Heck (66) during the second quarter at Candlestick Park in San Francisco, Sept. 1, 1990. The Seahawks beat the 49ers 30-10. (AP Photo/John Mabanglo)
Seattle Seahawks defensive tackle Sam Adams (98) fights his way through the blocking of 49ers offensive guard Derrick Deese (63) during a 9 to 13 Seattle Seahawks preseason loss to the San Francisco 49ers on August 26, 1994 at Candlestick Park in San Francisco, California. (AP Photo/Paul Spinelli)
Seattle Seahawks running back Ricky Watters (32) evades San Francisco 49ers' Monty Montgomery on a first-quarter run Saturday, Aug. 19, 2000, in Seattle. Watters made a first down on the play. (AP Photo/Elaine Thompson)
Seattle Seahawks running back Shaun Alexander (37) makes touchdown on Saturday, August 25, 2001, in San Francisco, California. The Seahawks defeated the 49ers 28-18 in a preseason game. (AP Photo/Al Golub)
Seattle Seahawks defensive back Reggie Tongue (25) moves in to finish off tackle on San Francisco 49ers wide receiver Tai Streets (89) on Sunday, December 1, 2002, in San Francisco, California. The 49ers defeated the Seahawks 31-24. (AP Photo/Al Golub)
Seattle Seahawks' Antonio Cochran (78) celebrates a fumble recovery by teammate safety Ken Hamlin on the first play after the 2-minute warning in the fourth quarter against the San Francisco 49ers, Sunday, Oct. 12, 2003, in Seattle. The Seahawks won 20-19. At left is 49ers' Ron Stone. (AP Photo/Elaine Thompson)
Seattle Seahawks' Ken Lucas (21) grabs San Francisco 49ers Jamal Robertson on a run in the fourth quarter Sunday, Sept. 26, 2004, in Seattle. Robertson was held to no gain on the play, and the Seahawks won, 34-0. (AP Photo/Elaine Thompson)
San Francisco 49ers' Shawntae Spencer, left, pushes Seattle Seahawks' Joe Jurevicius out of bounds on a first quarter pass reception, Sunday, Dec. 11, 2005, in Seattle. (AP Photo/Elaine Thompson)
Seattle Seahawks running back Shaun Alexander, front left, is brought down by San Francisco 49ers linebacker Manny Lawson, back, and linebacker Brandon Moore, right, in the second half of an NFL football game in San Francisco, Sunday, Nov. 19, 2006. San Francisco won 20-14. (AP Photo/Jeff Chiu)
Seattle Seahawks quarterback Matt Hasselbeck (8) smiles after greeting former teammate and San Francisco 49ers back-up quarterback Trent Dilfer after an NFL football game Monday, Nov. 12, 2007, in Seattle. The Seahawks won 24-0. (AP Photo/Elaine Thompson)
Seattle Seahawks running back Justin Forsett (30) is tackled by San Francisco 49ers running back Michael Robinson (24) during an NFL football game in San Francisco, Sunday, Oct. 26, 2008. (AP Photo/Paul Sakuma)
Seattle Seahawks quarterback Matt Hasselbeck (8) passes under pressure by San Francisco 49ers' Takeo Spikes in the fourth quarter during an NFL football game, Sunday, Dec. 6, 2009, in Seattle, Wash. Hasselbeck completed the pass to T.J. Houshmandzadeh. The Seahawks won 20-17. (AP Photo/Elaine Thompson)
Seattle Seahawks running back Michael Robinson #26 during an NFL football game between the Seattle Seahawks and the San Francisco 49ers December 12, 2010 at Candlestick Park in San Francisco Ca. The San Francisco 49ers defeated the Seattle Seahawks 40 - 21 in regular season week fourteen action. (Ap Photo/ Bill Nichols)
San Francisco 49ers defensive lineman Justin Smith (94) bull rushes the quarterback during an NFL game against Seattle Seahawks offensive lineman Robert Gallery (72) on Saturday, Dec. 24, 2011, in Seattle. The 49ers won the game, 19-17. (AP Photo/Greg Trott)
Seattle Seahawks wide receiver Doug Baldwin (89) catches a pass in front of San Francisco 49ers cornerback Chris Culliver (29) during the second quarter of an NFL football game in San Francisco, Thursday, Oct. 18, 2012. (AP Photo/Tony Avelar)
NFL Football: NFC Conference Playoff: San Francisco 49ers at Seattle Seahawks Game Action CenturyLink Field/Seattle, WA, USA 1/19/2014 X157457 TK1 Credit: Rod Mar
FILE - In this Jan. 26, 2014, file photo, Seattle Seahawks' Richard Sherman (25) tips a pass in the endzone intended for San Francisco 49ers' Michael Crabtree (15) in the final minute of the second half of the NFC championship NFL football game in Seattle. Seattle's Malcolm Smith intercepted the tipped pass. Sherman was fined $7,875 for unsportsmanlike conduct/taunting after he made a choking gesture after the play toward the San Francisco bench that he said was directed at quarterback Colin Kaepernick. (AP Photo/Marcio Jose Sanchez, File)
Seattle Seahawks running back Thomas Rawls (34) scores a touchdown between San Francisco 49ers middle linebacker Gerald Hodges (51), strong safety Jaquiski Tartt (29) and linebacker Michael Wilhoite (57) during the first half of an NFL football game in Santa Clara, Calif., Sunday, Jan. 1, 2017. (AP Photo/Tony Avelar)
Seahawks linebacker Bobby Wagner intercepts a 49ers pass near the goal line and heads upfield.
