Pro Football Talk's Mike Florio is taking the Chiefs to beat the Seahawks 30-21 in Week 16. "It's another AFC West reunion, and the team that owns the AFC West should remind Seattle why they should be glad that they got out when they did."
Vinnie Iyer of The Sporting News has the Chiefs defeating the Seahawks 34-26 by being dynamic with utilizing their run game on top of their prolific passing game. "Seattle will stay in the game with Kenneth Walker's running and DK Metcalf working on young corners minus Tyler Lockett. The Chiefs will figure out turning more to the run in the second half while Pete Carroll makes it interesting vs. Andy Reid for a while."
Karl Rasmussen of ClutchPoints predicts the Seahawks "stun" the Chiefs in overtime for their Week 16 matchup. "They'll need to take some big risks on offense and maybe hope for Tariq Woolen to come away with a turnover on defense, but a Seahawks win against the Chiefs would do wonders for their playoff push. I'm expecting this game to go to OT, despite the Chiefs' being considerable favorites, and for Seattle to come away with a jaw-dropping victory."
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Listen To The Seahawks Insiders Podcast
Hosted by sideline reporter Jen Mueller and Seahawks Senior Digital Media Reporter John Boyle, the Seahawks Insiders podcast takes an in-depth look at each week's Seahawks game and analyzes the previous week's matchup. Available on Spotify, Apple Podcasts, and wherever else you get your podcasts.
Matt Verderame of Fansided is picking the Chiefs to win at home against the Seahawks 30-23. "The Chiefs keep everybody in the game with their abysmal turnover ratio, but Kansas City has too much firepower for the sliding Seahawks."
Pete Prisco of CBS Sports NFL has the Chiefs "crushing" the Seahawks 35-21 in their Week 16 matchup. "The Chiefs are winning games, but they have looked off the past few weeks. Seattle has also struggled the past few games. This is a must-win for them, but this is a tough place to play. Their defense has major issues, which will show up here as Patrick Mahomes lights them up."
Chris Simms discussed on his show "Chris Simms Unbuttoned" about his prediction of the Week 16 game between the Chiefs and Seahawks is taking the Chiefs 38-27 in a cold matchup. "I expect a big day from Mahomes and company, and their running game and everything, they got it all on offense.'
3 staff members of Fansided's "12th Man Rising" are taking the Seahawks to upset the Chiefs in Arrowhead Stadium for Week 16. "The good thing is Geno Smith of the Seahawks can also move around well and will need to be as the Chiefs are fourth in the NFL in sacks (43) and eighth in pressure percentage (23,7 percent). Smith won't have Tyler Lockett to help either. DK Metcalf will need to be exceedingly good and find ways to get open on his own without having Lockett. Maybe Noah Fant will have his best game of 2022?"
The Seattle Seahawks take on the Kansas City Chiefs, the 53rd meeting between the two teams, for Week 16 of the 2022 season. Take a look back at some of their previous matchups.
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
Seattle Seahawks' John Sawyer, left, and Kansas City Chiefs' Jimbo Elrod, right, roll after the ball fumbled by Sawyer during the first quarter of their game at Arrowhead Stadium in Kansas City, Mo., Dec. 11, 1977. (AP Photo/John Filo)
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
Seattle Seahawks defensive back Dave Brown steps in front of Kansas City wide receiver Henry Marshall in route to his second interception return for a touchdown as the Seahawks shutout the Kansas City Chiefs 45-0, November 4, 1984. Brown combined with Keith Simpson and Kenny Easley to establish the NFL record for most interception returns for touchdowns at four. The three also combined with defensive back Terry Taylor, who intercepted two Chiefs passes that afternoon, to establish a new NFL mark for most interception return yardage in one game with 345 return yards (Brown 148 yards, Simpson 76, Easley 58, Taylor 43) Both records still stand going into the 2020 NFL season.
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Quarterback Todd Blackledge (14) of the Kansas City Chiefs, is grabbed by Jacob Green (79) of the Seattle Seahawks and sacked for a four-yard loss during the second quarter of their NFL game, Sept. 14, 1986. Also rushing Blackledge is Joe Nash (72) of the Seahawks. Seattle beat Kansas City 23-17. (AP Photo/Gary Stewart)
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
Quarterback Todd Blackledge, right, of the Kansas City Chiefs, is sacked for a seven-yard loss by linebacker Brian Bosworth, left, of the Seattle Seahawks, during the third quarter of their NFL game in Seattle, Wash., Sept. 20, 1987. Seattle beat Kansas City 43-14. (AP Photo/Barry Sweet)
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Seattle's David Wyman (92) brings down Kansas City's Christian Okoye (35) during the second half of Sunday, Oct. 8, 1989 NFL game in Seattle. The Chiefs won 20-16.(AP Photo/Billchan)
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
Running back Barry Word (23) of the Kansas City Chiefs runs past Cortez Kennedy (99) of the Seattle Seahawks for three of his 85 yards during the third quarter of NFL game in Seattle, Nov. 23, 1992. (AP Photo/Barry Sweet)
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
Kansas City Chiefs' running back Marcus Allen (32) manages to move the ball past the goal line for a first-quarter, one-yard touchdown in Seattle against the Seattle Seahawks, Dec. 5, 1993. Helping block for Allen is teammate Ernie Thompson (45). The Chiefs beat the Seahawks, 31-16. (AP Photo/Dick Downey)
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Seattle Seahawks fullback Steve Smith (35) heads into the end zone for a fourth quarter touchdown behind a block by teammate Howard Ballard (75) on Nov. 27, 1994 in Seattle against the Kansas City Chiefs. (AP Photo/Richard Downey)
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
Kansas City Chiefs Marcus Allen, left, (32) is hit by Seattle Seahawks Robert Blackmon (25) after 10-yard run in the first quarter at the Kingdome, Sunday, Sept. 3, 1995, Seattle, Wash. (AP Photo/Bill Chan)

The ball is just out of reach for Seattle Seahawks wide receiver Mike Pritchard during the first quarter Thursday, Oct. 17, 1996, at Arrowhead Stadium in Kansas City, Mo. Kansas City Chiefs cornerback Jerome Woods is a couple of steps behind on the incomplete pass play. (AP Photo/Orlin Wagner)

Kansas City Chiefs kicker Pete Stoyanovich (10) kicks the game winning field goal over Seattle Seahawks defender Chad Brown (94) in overtime Sunday, Sept. 28, 1997, in Kansas City, Mo. The Chiefs beat the Seahawks 20-17. (AP Photo/Orlin Wagner)
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
Seattle Seahawks Darrin Smith (59) high steps it into the end zone for a touchdown in the second quarter of their game against Kansas City Sunday, Nov. 8, 1998 in Seattle. Smith intercepted a Elvis Grbac pass and ran it back 26 yards for the score. (AP Photo/Rick Giase)
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Seattle Seahawks' Christian Fauria runs ahead of Kansas City Chiefs' Donnie Edwards after catching a pass in the third quarter in Seattle on Sunday, Dec. 26, 1999. (AP Photo/Lauren McFalls)

Seattle Seahawks quarterback Jon Kitna throws a touchdown pass to Derrick Mays under pressure from Kansas City Chiefs' Eric Hicks (98) and Chester McGlockton (75) as Seahawks' Brian Habib (68) looks on during the second quarter in Seattle on Sunday, Dec. 26, 1999. The Seahawks won 23-14. (AP Photo/Matt Wallis)
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Seattle Seahawks' Shaun Alexander leaps into the end zone for a touchdown on a 3-yard run past Kansas City Chiefs defender Ray Crockett in the second quarter in Seattle, Sunday, Nov. 24, 2002. (AP Photo/John Froschauer)
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Seattle Seahawks running back Shaun Alexander (37) follows the blocks of Seahawks center Robbie Tobeck (61) and guard Floyd Wedderburn during the Seahawks 39 to 31 victory over the Kansas City Chiefs at Seahawks Stadium, 11/24/2002.©Corky Trewin/NFL Photos

Seattle Seahawks running back Shaun Alexander (37) scores his second touchdown of the game, a 46 yard fourth quarter run, as the Seahawks defeated the Kansas City Chiefs 39 to 32 at Seahawks Stadium, 11/24/2002.©Corky Trewin/NFL Photos
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Seattle Seahawks wide receiver Bobby Engram (84) runs with the ball as Kansas City Chiefs defensive back Ray Crockett (39) tries to tackle during the Seahawks 39 to 32 vcitory at Seahawks Stadium, 11/24/2002.©Corky Trewin/NFL Photos
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Seattle Seahawks wide receiver Darrell Jackson (81) speeds up field during the Seahawks 39 to 32 victory over the Kansas City Chiefs at Seahawks Stadium, 11/24/2002. ©Corky Trewin/NFL Photos

Seattle Seahawks tight end Jerramy Stevens (86) catches this ball over Kansas City defensive back Eric Warfield (44) for his first NFL touchdown reception during the Seahawks 39 to 32 victory over the Chiefs at Seahawks Stadium, 11/24/2002.©Corky Trewin/NFL Photos
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
Seattle Seahawks wide receiver Deion Branch (83) is pushed out of bounds by Kansas City Chiefs cornerback Lenny Walls (35) just short of the goal line late in the third quarter of their football game in Kansas City, Mo., Sunday, Oct. 29, 2006. (AP Photo/Reed Hoffmann)
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Seattle Seahawks Chris Baker drives across the end zone to score a touchdown against Kansas City Chiefs Kendrick Lewis in the second half of an NFL football game, Sunday, Nov. 28, 2010, in Seattle. (AP Photo/Ted S. Warren)
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Seattle Seahawks quarterback Matt Hasselbeck in action against the Kansas City Chiefs in the second half of an NFL football game, Sunday, Nov. 28, 2010, in Seattle. (AP Photo/Elaine Thompson)
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Seattle Seahawks center Max Unger (60) faces the Kansas City Chiefs line, in the first half of an NFL football game in Kansas City, Mo., Sunday, Nov. 16, 2014. (AP Photo/Charlie Neibergall)
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Seattle Seahawks running back Marshawn Lynch (24) carries the ball past Kansas City Chiefs inside linebacker James-Michael Johnson (52) in the first half of an NFL football game in Kansas City, Mo., Sunday, Nov. 16, 2014. (AP Photo/Ed Zurga)