The Seahawks will be missing several key players for Sunday's game against the 49ers, including All-Pro safety Jamal Adams and starting running back Chris Carson, who were both listed as questionable on Friday's injury report.

Also out are starting defensive end Benson Mayowa, who was listed as questionable with an ankle injury, and three players who were listed as doubtful: starting left guard Mike Iupati, nickel defensive back Ugo Amadi and running back Carlos Hyde. The Seahawks also ruled out Pro-Bowl cornerback Shaquill Griffin on Friday.

Travis Homer, who was listed as questionable with a knee injury, is active, giving the Seahawks two active running backs in Homer and rookie DeeJay Dallas. Also active after being listed as questionable is safety Ryan Neal, who has started the past three games in place of Adams.

Four players added yesterday are all active, cornerback D.J. Reed and tight end Colby Parkinson, who were activated off of the non-football injury list, and defensive end/tight end Stephen Sullivan and cornerback Jayson Stanley, who were elevated from the practice squad.

Reed could be an option to replace Amadi in the nickel role, as could cornerback Linden Stephens. Sullivan, who was drafted out of LSU as a tight end, has been working at defensive end for several weeks in practice and could be part of the pass-rush rotation, especially given Mayowa's absence.

Here are the inactives for both teams:

Seattle Seahawks

CB Shaquill Griffin

S Ugo Amadi

RB Carlos Hyde

RB Chris Carson

S Jamal Adams

G Mike Iupati

DE Benson Mayowa

San Francisco 49ers

QB C.J. Beathard

WR Richie James

WR Deebo Samuel

S Jaquiski Tartt

CB Ken Webster

LB Kwon Alexander